Viral evolution

Although current anti-HIV therapy significantly reduces the risk of AIDS, many HIV-infected individuals will develop HIV-associated co-morbidities such as atherosclerosis, neurological disease and a variety of cancers. This trend suggests a link between viral-associated inflammation and disease. We investigate the associations between viral genetic variants and their evolutionary trajectories during the development of these pathologies. These studies combine our bioinformatics background with our understanding of pathology and immunology.